郗日沫

男

教授

所在单位：5357cc拉斯维加斯

学科方向：分子生物学及免疫分析诊断方法的应用；拉曼成像与光敏诊疗的应用研究

招生方向：药物化学；微生物与生化药学；生物与医药

课题组成员

副教授：孟萌

副教授：尹永梅

天津市我校津南校区我院237

传真：022-22507760

Email：xirimo@nankai.edu.cn

教师简介

男，日本文部省冈崎国立共同研究机构分子科学研究所理学博士。1962年5月出生于内蒙古。1980年考入我校化学系，1987年毕业获化学硕士学位。1987年至1990年在北京大学化学系攻读博士学位。1992年3月进入日本冈崎国立共同研究机构-分子科学研究所，三年后，于1995年4月获理学博士学位。1995年至1997年在美国芝加哥大学化学系从事博士后研究。1997年至1998年在美国威斯康星大学麦迪逊分校任博士后研究员。从1998-2003起，在美国生物技术公司从事生物技术免疫诊断试剂的研究，开发和市场化。2003年3月，成为山东大学化学与化工学院教授，组建了食品中药物残留免疫快速检测实验室，专门从事食品残留药物的免疫原的合成和相应免疫检测方法的研究。2009年1月，调到5357cc拉斯维加斯担任药物分析教授，从事血药浓度检测及电化学免疫分析。

教育经历

Postdoc. (1997-1998): Chemistry, The Universiyt of Wisconsin-Madison, USA.

Postdoc. (1995-1997): Chemistry, The University of Chicago, Chicago, USA.

Ph.D. (1992-1995): Chemistry, Institute for Molecular Science, Okazaki, Japan.

M.S. (1984-1987): Chemistry, Nankai University, Tianjin, China.

B.S. (1980-1984): Chemistry, Nankai University, Tianjin, China.

研究领域和兴趣

1.病理抗体制备和IHC检测技术研发.

2.肿瘤伴随诊断技术的研究开发.

3.小分子抗原的合成和多克隆/单克隆抗体制备

4.生物免疫技术药物残留检测方法的研究和开发

5.血药浓度监测关键抗体试剂的联合研发

6.电化学免疫分析法的建立及应用

主持的科研项目

1.国家科技部重大国际科技合作项目(主持人)，2015DFR40460，血药浓度监测关键抗体试剂的联合研发，2015.4-2018.3.

2.国家科技部863计划(主持人), 2014AA022303,儿童营养素抗体检测技术体系的建立, 2014.12-2016.12.

3.国家科技部863计划(主持人), 2007AA10z435,重要禁用兽药快速免疫检测技术及产品, 2007.8-2010.10.

4.国家科技部重大863计划(子课题主持人), 2007AA06A407，重大环境污染事件特征污染物实验室检测技术系统，2007.11-2010.11

5.国家自然科学基金-面上项目(主持人)，81173017、新药筛选关键技术甲基化转移酶活性的免疫检测体系的研究、2012/1-2015/12.

6.国家自然科学基金-面上项目(主持人), 20685048,硝极呋喃类药物抗体的制备和酶联免疫分析法的建立, 2007.1-2009.12.

7.天津市中高端医疗器械重大专项(主持人),糖化血红蛋白即时检测产品的开发研究, 2016/12-2019/12.

8.天津市科技支撑计划重点项目(主持人)，11ZCGHHZ01200、喹诺酮药物的多残留检测及抗体亲和力构效关系的分子模拟研究、2011/10-2013/09

9.天津市科技计划项目(主持人)，13JCZDJC29700、食品中的邻苯二甲酸酯的快速荧光偏振免疫分析方法研究、2013/04-2016/03；

代表性论文：

1. Xiujie Zhao, Hongjie Zhao, Shuo Wang, Zhiwen Fan, Yan Ma, Yongmei Yin, Wei Wang, Rimo Xi,* and Meng Meng*, A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy, J. Am. Chem. Soc. 2021, 143, 20828−20836.

2. Ying Zhang, Qian Liu, Mengting Liu, Xueni Zhang, Xiaoya Li, Lihui Dai, Meng Meng, Dingbin Liu, Yongmei Yin*, Rimo Xi*, Dual functional molecule aided background-free SERS sensor for intracellular pH dynamic monitoring based on foldable DNA transition, Sensors & Actuators: B. Chemical 353 (2022) 131162.

3. Qian Liu, Fang Wu, Huixia Di, Yingna Bi, Meng Meng, Dingbin Liu, Yongmei Yin*, Rimo Xi*, A novel SERS biosensor for ultrasensitive detection of mercury(II) in complex biological samples, Sensors & Actuators: B. Chemical 351 (2022) 130934.

4. Qian Liu, Xinmin Yue, Yixian Li, Fang Wu, Meng Meng, Yongmei Yin*, Rimo Xi*, A novel electrochemical aptasensor for exosomes determination and release based on specific host-guest interactions between cucurbit [7]uril and ferrocene, Talanta 232 (2021) 122451.

5. Xinmin Yue, Yanqi Qiao, Dening Gu, Rui Qi, Hongjie Zhao, Yongmei Yin, Wei Zhao, Rimo Xi* and Meng Meng*, DNA-Based pH Nanosensor with Adjustable FRET Responses to Track Lysosomes and pH Fluctuations, Anal. Chem. 2021, 93, 7250−7257.

6. Kai Wang, Ruixiao Zhang, Xinmin Yue, Zheng Zhou, Lihuan Bai, Yue Tong, Bei Wang, Dening Gu, Shuo Wang, Yanqi Qiao, Qian Liu, Xue Xue, Yongmei Yin, Rimo Xi*, Meng Meng*, Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, ACS Sens. 2021, 6, 1543−1551.

7. Yanqi Qiao, Qingqing Xue, Xinmin Yue, Yang Liu, Qian Liu, Xiujie Zhao, Dening Gu, Shuo Wang, Kai Wang, Yongmei Yin, Jing Li, Rimo Xi*, Meng Meng*, A DNA nanoscaffold-based electrochemical assay for sensitive determination of O-GlcNAc transferase (OGT) activity and its application in cell-permeable OGT inhibitors screening, Sensors & Actuators: B. Chemical 334 (2021) 129665.

8. Xiujie Zhao, Zhiwen Fan, Yanqi Qiao, Yun Chen, Shuo Wang, Xinmin Yue, Tangliang Shen, Wenting Liu, Jie Yang, Heqi Gao, Xuelin Zhan, Luqing Shang, Yongmei Yin, Wei Zhao, Dan Ding, Rimo Xi*, Meng Meng*, AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780, ACS Appl. Mater. Interfaces, 2020, 12: 16114–16124.

9. Xiujie Zhao, Yun Chen, Guiyu Niu, Dening Gu, Jianning Wang, Yanmei Cao, Yongmei Yin, Xiaogang Li, Dan Ding, Rimo Xi* and Meng Meng*, Photostable pH-Sensitive Near-Infrared Aggregation-Induced Emission Luminogen for Long-Term Mitochondrial Tracking, ACS Appl. Mater. Interfaces, 2019, 11: 13134–13139.

10. Xinmin Yue, Yanqi Qiao, Dening Gu, Zixuan Wu, Wenhui Zhao, Xiaoyu Li, Yongmei Yin, Wei Zhao, Deming Kong, Rimo Xi*, Meng Meng*, Reliable FRET-ON imaging of telomerase in living cells by a tetrahedral DNA nanoprobe integrated with structure-switchable molecular beacon, Sensors & Actuators: B. Chemical 2020, 312, 127943.

11. Li Xiaogang#, Liu Wei#, Yue Xinmin, Song Pei, Yin Yongmei, Meng Meng*, Xi Rimo*, A competitive immunoassay using hapten-modified polydiacetylene vesicles for homogeneous and sensitive detection of sodium benzoate, Sensors and Actuators B: Chemical, 2018, 258: 1060–1065.

12. Xiaogang Li, Meng Meng*, Lei Zheng, Zhihuan Xu, Pei Song, Yongmei Yin, Sergei A. Eremin and Rimo Xi*, Chemiluminescence Immunoassay for S-Adenosylhomocysteine Detection and Its Application in DNA Methyltransferase Activity Evaluation and Inhibitors Screening, Anal. Chem., 2016, 88 (17), pp 8556–8561.

13. Lisha Zhang, Pei Song, Hao Long, Meng Meng, Yongmei Yin*, Rimo Xi*, Magnetism based electrochemical immunosensor for chiral separation of amlodipine, Sensors and Actuators B: Chemical, 248 (2017) 682–689.

14. Kun Xu, Hao Long, Rongge Xing, Meng Meng*, Rimo Xi*, A sensitive chemiluminescent immunoassay to detect Chromotrope FB (Chr FB) in foods, Talanta, 2017, 164: 341–347.

15. L.S. Zhang, Z.R. Song, Y.Q. Dong, Y.F. Wang, X.G. Li, H. Long, K. Xu, C. Deng, M. Meng, Y.M. Yin*, R.M. Xi*, Enantiomeric separation of 1,4-dihydropyridines by liquid-phase microextraction with supercritical fluid chromatography, J. Supercrit. Fluids 107 (2016) 129-136.

16. Yaqing Dong, Jie Zhang, Yue Xing, Zhaorui Song, Yufen Wang, Meng Meng, Chuan Deng, Zhongsheng Tong, Yongmei Yin*, and Rimo Xi*, Quantification of Ponceau 4R in Foods by Indirect Competitive Enzyme-Linked Immunosorbent Assay (icELISA), J. Agric. Food Chem., 2015,63 (28): 6338-6345.

17. Lei Zheng#, Jing Wang#, Yufen Wang, Zhaorui Song, Yaqing Dong, Yongmei Yin & Sergei A. Eremin, Meng Meng*, Rimo Xi*, A sensitive chemiluminescent immunoassay for point-of-care testing of repaglinide in natural dietary supplements and serum, Anal. Bioanal. Chem., 2015, 407:1973–1980.

18. Linlin Ren, Meng Meng, Peng Wang, Zhihuan Xu, Sergei A. Eremin, Junhong Zhao, Yongmei Yin*, Rimo Xi*, Determination of sodium benzoate in food products by fluorescence polarization immunoassay. Talanta, 121 (2014) 136-143.

19. Yue Xing, Meng Meng, Huyin Xue, Taichang Zhang, Yongmei Yin*, Rimo Xi*. Development of a polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for detection of Sunset Yellow FCF in food samples. Talanta, 2012, 99: 125–131.

20. Xiaoling Fu, Meng Meng*, Yu Zhang, Yongmei Yin, Xiangsheng Zhang*, Rimo Xi*, Chemiluminescence enzyme immunoassay using magnetic nanoparticles for detection of neuron specific enolase in human serum, Analytica Chimica Acta, 2012, 722: 114–118.