姓名：山长亮
职称：教授 我校百名青年学科带头人
学科方向：肿瘤药理、分子生物学和细胞生物学
研究方向：肿瘤代谢酶表观调控与化学干预
通讯地址：天津市津南区同砚路38号5357cc拉斯维加斯102室
电子邮件：changliangshan@nankai.edu.cn
教师简介：
教育背景
2011年 获我校 生物化学与分子生物学 博士
2006年 获鲁东大学 生物技术 本科
工作经历
2018年12月~至今 5357cc拉斯维加斯 教授 博导
2015年6月~2018年11月 暨南大学生物医学转化研究院 研究员 博导
2015年1月~2015年5月 上海药物研究所 客座研究员
2011年9月~2014年12月 美国Emory 大学医学院 博后
个人专长
山长亮博士长期从事肿瘤代谢酶调控与化学干预研究。发表学术论文50余篇，总引用>2500次，h-index=26。其中以第一（含共同）和通讯（含共同）作者发表论文24篇，包括Nature Cell Biology, Nature Chemistry, Molecular Cell （2篇）, Acta Pharmaceutica Sinica B (APSB), Clinical and Translational Medicine, Cancer Letter, J. Biol. Chem, Cell Research, Biochemical Pharmacology （2篇）, Cell Death & Disease（2篇）, Biomedicines, Carcinogenesis （2篇, １篇高被引论文）, European Journal of Medicinal Chemistry, Int J Mol Sci, FEBS Lett, Bioorg Med Chem Lett和Front. Pharmacol （4篇）。
学术兼职
中国抗癌协会抗癌药物专业委员会第六、七届委员会委员
中国抗癌协会肿瘤标志专业委员会青年委员
中国细胞生物学学会肿瘤细胞生物学学会分会委员
中国细胞生物学学会细胞代谢分会委员
中国抗癌协会肿瘤细胞代谢分会委员
中国抗癌协会非编码RNA与肿瘤研究专家委员会常委
代表性论文：（*通讯作者#第一作者）
1. Wang J*, Chang H, Quan X, Dai X, Wang Y, Wang C, Zhang S*, Shan C*. A model for identification of potential phase-separated proteins based on protein sequence, structure and cellular distribution. Int J Biol Macromol. 2023 Jun 5:125196.
2. Xie F, Zhang H, Zhu K, Jiang CS, Zhang X, Chang H, Qiao Y, Sun M, Wang J, Wang M, Tan J, Wang T, Zhao L, Zhang Y, Lin J, Zhang C, Liu S, Zhao J*, Luo C*, Zhang S*, Shan C*. PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1. MedComm (2020). 2023 Mar 28;4(2):e245.
3. Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH*, Luo C*, Zhang S*, Shan C*. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023 Jan;13(1):157-173.
4. Wang J, Qiao Y, Sun M, Sun H, Xie F, Chang H, Wang Y, Song J, Lai S, Yang C, Li X, Liu S, Zhao X, Ni K, Meng K, Zhang S*, Shan C*, Zhang C*, FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1.Clinical and Translational Medicine.2022. DOI: 10.1002/ctm2.772
5. Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S*, Shan C*, Zhang S*. PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3. Biochem Pharmacol. 2021 Oct;192:114736.
6. Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S*, Shan C*. Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1. Biochem Pharmacol. 2020 Aug;178:114092.
7. Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S*, Shan C*. YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020 Jul 10;41(5):541-550.2
8. Li Y, Liang R, Sun M, Li Z, Sheng H, Wang J, Xu P, Liu S, Yang W, Lu B, Zhang S*, Shan C*. AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 2020 May 28;478:82-92.2
9. Shan C*,#, Lu Z, Li Z, Sheng H, Fan J, Qi Q, Liu S, Zhang S*. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019 Jul 8;10(7):525.
10. Zhang S, Sheng H, Zhang X, Qi Q, Chan CB, Li L, Shan C*, Ye K*. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death Dis. 2019 Mar 4;10(3):222.
11. Zheng W, Feng Q, Liu J, Guo Y, Gao L, Li R, Xu M, Yan G, Yin Z, Zhang S*, Liu S*, Shan C*. Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. Front Pharmacol. 2017 Jun 30;8:421.eCollection 2017.
12. Wang J#, Luo C#, Shan C#, You Q#, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J, Jiang H, He C. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79.
13. Lin R#, Elf S#, Shan C#, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.
14. Shan C#, Elf S#, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21;55(4):552-65.
15. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. J Biol Chem. 2014 Aug 1;289(31):21413- 22.
16. Fan J#, Shan C#, Kang HB#, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014 Feb 20;53(4):534-48.
17. Shan C#, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Ye L, Zhang X. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis. 2011, 32(8):1190-7.
18. Shan C#, Xu F. Zhang S, You J, You X, Qiu L, Zheng J, Ye L, Zhang X. Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2. Cell Res. 2010, 20(5):563-75.